Samer Siwani

  • Reading stones Part I: What fossil skulls tell us about the brains of the dead

    An interview with palaeontologist Hady George, a PhD student in Professor Emily Rayfield’s group at the University of Bristol, who has worked on the endocasts of stem-mammals (George et al., 2024) and dinosaurs including T. rex (Caspar et al., 2024). In this article series I will summarise some of what we know, how we know…

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  • The psychedelic brain is quietly ordered, not chaotic, according to new study

    The largest single-site psychedelic neuroimaging study to date finds that psilocybin doesn’t simply disorder the brain’s activity. Under the drug, brain dynamics became more structured, not less, and the strength of that structure tracked how intense and meaningful participants found the experience. The apparent “chaos” reported by earlier studies may be an artefact of how…

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  • Most neurons are Jacks-of-all-trades, not specialists

    A prevailing hypothesis in neuroscience is that individual neurons are selective for a function (Hirokawa et al., 2019), specialised for a particular task. However, more and more papers are published invoking differential functions and behavioural effects for the same neuron types. The categorical selectivity may not be the rule, but an exception, according to a…

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  • Beyond Descartes: Non-Western foundations of Neuroscience

    Modern neuroscience typically teaches a history that begins with the ancient Greeks, skips nearly two thousand years, and resumes with European thinkers of the Renaissance. This narrative ignores non-Western discoveries entirely, and reinforces a Eurocentric story in which progress radiates outward from Europe. In reality, during those “silent” centuries, scholars across the Islamic world, India,…

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  • What striatal replay reveals about the brain’s hidden architecture

    A study published in July in Nature Neuroscience by Thompson et al. has revealed that replay and consolidation of procedural memories do occur during sleep; however, the process involves another structure called the striatum (associated with motor/procedural functions), and not the hippocampus.

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  • Function or phantom? Why brain wave function remains  a mystery

    Most of the general public are familiar with brainwaves. However, a very small minority are aware of the uncertainty that prevails in the electrophysiology field. Ever since the first recorded signal by Hans Berger (Berger, 1929), alpha waves, most prominent in the visual cortex, we have been bewildered as to what they are. Mathematically minded…

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  • Menstrual health: Could mindfulness be a low-risk supplement for PMS?

    Researchers systematically reviewed existing studies (18) on psychological and biological outcomes of mindfulness-based interventions for premenstrual syndrome (PMS) in a total of 1,080 individuals.

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  • Lab-grown stem cell treatment of patients with Parkinson’s disease demonstrates feasibility

    Swedish News, In a Phase 1/2 open-label trial out of a collaboration between Lund and Cambridge universities, and conducted in Skåne University Hospital. Researchers evaluated the therapeutic potential of transplanting laboratory-produced dopaminergic progenitor cells into the brains of Parkinson’s patients. Earlier approaches relied on fetal tissue donations, which face significant supply constraints. The progenitor cells…

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  • When 80% of seizures are silent: How edge AI could save newborn brains. An interview with Professor Richardson Leao.

    Imagine a $200 device replacing $10,000/month monitoring solution that can detect the invisible seizures in newborns, using AI-powered neonatal EEG for resource-limited settings. A device that allows for effective neonatal neuroprotection in developing countries and beyond. Neonatal seizures can be a massive problem due to their subclinical symptomatology. They are essentially invisible. Approximately 50-80% of…

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  • Emotions in animals and the anthropomorphic leap

    Opinion, You see your dog whine when you leave. Does he feel sadness, or is he just reacting? And how could you possibly know? If you would attempt to answer that question empirically, you would struggle greatly. Because emotions are a concept defined by humans to describe experiences we believe are universal. However, experiences may…

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